Alex Hall

Upcoming Seminar

David Gonzalez (UCLA), Why Do Particles Make People Sick? Reactive Oxygen from Biomass Burning Components in Simulated and Human Lung Fluids

Wed, Jan 23, 2019

MSA 7124

ABSTRACT

Epidemiological studies have shown that inhalation of ambient particulate matter is associated with increased cardiovascular diseases, respiratory diseases, cancer and premature death. However, the particle components and underlying mechanisms that contribute to particle toxicity are poorly understood. Inhaled particles may contribute to health effects by producing an excess reactive oxygen species (ROS) in physiological systems. ROS are a class of reactive oxygen-bearing compounds that include the hydroxyl radical (OH), hydrogen peroxide and superoxide. Of all ROS, the OH radical may be the most damaging, capable of capable of oxidizing DNA, proteins and lipids. Particle components that contribute to OH generation under physiological conditions are not well known. Our research develops methods for investigating mechanisms of ROS generation and identifying toxic particle components. Through a combination of laboratory experiments, thermodynamic and chemical kinetic modeling, we explore the following: (1) Measurement of OH radicals with the “terephthalate probe” (2) Reaction mechanisms of OH radical generation from biomass burning components in lung fluid (3) Quantifying malondialdehyde in particulate matter samples.

Specialty: Climate Dynamics

alexhall [at] atmos.ucla.edu

Professor/Vice Chair

MSA 7955

http://research.atmos.ucla.edu/csrl/

58°

Fog

ABSTRACT

Campus Address

Mailing Address

Contact Information

Campus Address	Mailing Address	Contact Information
520 Portola Plaza	UCLA Atmospheric & Oceanic Sciences	Students Services Office: (310) 825-1954
Math Sciences Building 7127	Box 951565	Email: studentinfo@atmos.ucla.edu
Los Angeles, CA 90095	Los Angeles, CA 90095-1565	Phone: (310) 825-1217